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Product name:Galantamine Hydrobromide |
CAS:1953-04-4 |
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MF:C17H22BrNO3 |
MW:368.27 |
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EINECS:217-780-5 |
Place of Origin:Shanxi,China |
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Type:Cholinesterase inhibitors |
Brand Name:Tihondan |
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Shelf Life:24Mothod |
Purity:99% |
Packaging Details
Sample order (10-20g):Double plastic bags inside and foil bag outside
Bulk order (over 25kg):Double plastic bag and fiber drum (N.W: 25kgs. I.D. 35 x H51 cm)
Customized package available
Port
China main port
Leading time
|
Quantity(kilograms) |
1 - 1 |
2 - 500 |
501 - 1000 |
>1000 |
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Est. Time(days) |
5 |
7 |
10 |
To be negotiated |
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Melting point：256 °C |
alpha：D20 -93.1° (c = 0.1015 in 15 ml H2O) |
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form ：White to off-white crystalline solid. |
refractive index ：-95 ° (C=1.4, H2O) |
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Water Solubility：Soluble in water or DMSO |
storage temp. ：Inert atmosphere,Store in freezer, under -20°C |
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solubility：Sparingly soluble in water, very slightly soluble in anhydrous ethanol. It dissolves in dilute solutions of alkali hydroxides. |
Product description:Galantamine hydrobromide is the hydrobromide salt of galantamine and is a cholinesterase inhibitor can be extracted from Amaryllidaceae Lycoris plant. The III-phase clinical trials in the United Kingdom in 1998 have showed that this drug had dual mechanism of action of both inhibiting acetylcholinesterase and regulating nicotinic receptors. Therefore, galantamine can improve the cognitive abilities of Alzheimer's patients and has been already applied as the drug of the treatment of mild to severe Alzheimer's disease (AD) drugs and has entered into market in EC countries. "Chinese Pharmacopoeia" has included the both the raw material and injection of galantamine hydrobromide. It is clinically mainly used for the treatment of poliomyelitis (polio) sequelae, muscular dystrophy and myasthenia gravis. It can be used to substitute neostigmine methyl-sulfate for antagonism of tubocurarine but with weak performance with the usage amount being ten times as high as the usage amount of neostigmine methyl-sulfate. Intravenous injection of 0.5 mg/kg of galantamine hydrobromide can quickly reverse the central anticholinergic effects caused through injection of scopolamine hydrobromide. It can also be used for treating children cerebral palsy, traumatic sensorimotor disorders, multiple neuritis and radiculitis.
Symbol(GHS)
Signal word ：Danger
Hazard statements：H300
Precautionary statements ：P264-P270-P301+P310a-P321-P405-P501a
Hazard Codes ：T
Risk Statements ：25
Safety Statements：45-36/37/39-22
RIDADR：UN 2811 6.1/PG 3
WGK Germany ：3
RTECS ：DF8075000
HazardClass：6.1
PackingGroup ：II
HS Code：29399990
Toxicity：LD50 i.v. in mice (mg/kg): 5.2 ± 0.2 (Friess)
COA&MSDS
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