Company Profile
Shanxi Tihondan Pharmaceutical Technology Co. , Ltd. , registered in 2021 October, is reorganized and established by Shanxi Xuanran Pharmaceutical Technology Co. , Ltd. . It is located in the Paul Big Health Industrial Park of Shanxi Transformation and comprehensive reform demonstration zone in Jinzhong, close to Taiyuan, South Station, Taiyuan Wusu International Airport.
Tihondan is mainly engaged in CRO , CMO , CDMO business, covering the entire pre-clinical life cycle of drugs, in the line design and development, process development and verification, total quality control and other aspects to provide customers with timely, high-quality, low-cost full-scale service.
Tihondan adopte with the most advanced processing technology and equipments, specializes in research and development of Creatine monohydrate, 3-Amino-4-pyrazolecarboxamide hemisulfate, 3,4-Dimethylbenzaldehyde and continuing to develop in advance science . Tihondan is committed to focus and provide both safe environment and development, and strives to build into a green environmental establishment.
Synthetic Chemistry
Tihondan has been deeply involved in the field of small molecule synthesis, serving more than 100 domestic and international customers, synthesizing tens of thousands of small molecule compounds for world-renowned pharmaceutical companies, and successfully enrolling and optimizing process for a number of new drug candidate compounds.
（1）Our synthetic chemistry services include:
（2）Chemical synthesis at pre-clinical stage
（3）Customized synthesis of high-end products
（4）Catalogs of pharmaceutical intermediates and building blocks
Special synthetic requests such as chiral compounds, antibody drug conjugates (ADC), and drug impurity standards.
We adhere to technological innovation and always take advantage of the industry's leading chemical synthesis technology. Our cooperation is in line with the leading pharmaceutical industry in Europe and America and has accumulated rich experience in the synthesis of innovative drugs. Our core team has strong technical research capabilities to ensure the smooth progress of the project and help customers to quickly promote research and development projects.
Full-time equivalent (FTE) service
Tihondan has a team of highly skilled medicinal chemists, advanced R&D equipment, and comprehensive R&D resources. Through our CRO management model, we have constructed a high-tech, high-efficiency, high-strain chemical synthesis platform. We are always providing the best quality with cost efficiency in order to help customers complete drug candidate development.
Customized synthesis
Tihondan has established a dedicated customized synthesis department. Our R&D department and project management department work together to make sure the progress is on track with fast delivery capabilities. High delivery rate and high product quality have won us a high degree of trust from our customers, and thus we have maintained long-term cooperative relationships with many pharmaceutical companies worldwide.
Analytical chemistry
Tihondan has constructed a database of impurities, together with a comprehensive literature searching system, and a highly skilled team featured with expertise in both synthesis and analysis. We have in-depth regulatory knowledge, as well as bilingual (English and Chinese) ability to help respond to major regulatory agencies. Our core business includes genotoxic impurities research, related substance testing, residual solvent testing, analytical testing services, etc.
Great for the dog park!!
"My two young labs absolutely love this toy. They are rough on toys, so we have to work with them on not trying to destroy a toy the moment it is given to them.
This "flying squirrel" immediately became and continues to be a high value toy, so it is put up and out of the way when not being played with. Lightweight and flexible, but even so, the toy is really durable.”
Process Development And Production
Tihondan offers process development and production services covering all stages of drug discovery and development. Our executive leadership team is a group of senior chemists with more than 25 years of experience in process development and production in pharmaceutical industry. Our highly skilled scientist are talents in the field of organic synthesis, with rich experience in process development and production. We have successfully assisted customers from well-known pharmaceutical companies to advance hundreds of molecules through development to production.
Infrastructure：The kilogram laboratory is equipped with a 20-50L reactor, whilst the pilot plant is equipped with a 100L-1000L reactor. It is equipped with a distillation unit, autoclaves & commercial sterilizers, and pulverizer. In addition to meeting the conventional reaction conditions, our pilot platform can also achieve high and low temperature reactions, anhydrous anoxic reactions, hydrogenation reactions, nitrification reactions, acid-base reactions, enzyme catalytic reactions, etc.
Process Development
（1）Contract Manufacturing Organization
（2）Route scouting and Assessment of Critical Process Parameters
（3）Process optimization
（4）Analysis and identification of impurities
（5）Process technology transfer
（6）Process validation
Customized Synthesis
（1）Provide high quality, cost effective customized synthesis services from kilo to metric ton scale
（2）Expertise in overcoming difficult synthesis processes
（3）Experienced in fast delivery
Pilot and Commercial Production
Tihondan has Shanxi Xingtianyuan as production base，relying on the international standard quality system and large-scale commercial GMP production experience，abides the highest quality standards, with a high degree of professionalism, excellent service record and rich project management experience, can meet the different needs of domestic and foreign customers in each stage, to provide customers with a complete set of R & D and production services.
